IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against <i>M. tb</i> Challenge

IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against <i>M. tb</i> Challenge

Intravenously (IV) delivered BCG provides superior tuberculosis (TB) protection compared with the intradermal (ID) route in non-human primates (NHPs). We examined how γδ T cell responses changed in vivo after IV BCG vaccination of NHPs, and whether these correlated with protection against aerosol &l...

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Bibliographic Details
Main Authors: Alexandra L. Morrison, Charlotte Sarfas, Laura Sibley, Jessica Williams, Adam Mabbutt, Mike J. Dennis, Steve Lawrence, Andrew D. White, Mark Bodman-Smith, Sally A. Sharpe
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Vaccines
Subjects:
BCG
γδ T cells
tuberculosis
Online Access:https://www.mdpi.com/2076-393X/11/10/1604

Internet

https://www.mdpi.com/2076-393X/11/10/1604

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