Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis

Background: Radiobiological model-based studies of photon-modulated radiotherapy for pancreatic cancer have reported reduced gastrointestinal (GI) toxicity, although the risk is still high. The purpose of this study was to investigate the potential of 3D-passive scattering proton beam therapy (3D-PS...

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Bibliographic Details
Main Authors: Vijay P. Raturi, Taku Tochinai, Hidehiro Hojo, Toshiya Rachi, Kenji Hotta, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Takaki Ariji, Yasuhiro Hirano, Hiromi Baba, Hajime Ohyoshi, Masaki Nakamura, Masayuki Okumura, Yanping Bei, Tetsuo Akimoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
normal tissue complication probability (NTCP)
intensity modulated radiation therapy (IMRT)
volumetric modulated arc therapy (VMAT)
proton beam therapy (PBT)
dosimetry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.517061/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.517061/full

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