Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

Staphylococcus aureus α-toxin impairs early neutrophil localization via electrogenic disruption of store-operated calcium entry

Summary: The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis. While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to lysis, suggesting that the action of Hla may not be solely conferred by lytic susceptibility. Using in...

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Bibliographic Details
Main Authors: Fan Yang, Mingyi Suo, Homayemem Weli, Mason Wong, Alex Junidi, Celeste Cummings, Ryan Johnson, Kiara Mallory, Annie Y. Liu, Zev J. Greenberg, Laura G. Schuettpelz, Mark J. Miller, Cliff J. Luke, Gwendalyn J. Randolph, Bernd H. Zinselmeyer, Juliane Bubeck Wardenburg, Regina A. Clemens
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014067

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723014067

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