Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults – a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trialResearch in context

Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults – a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trialResearch in context

Summary: Background: Ivermectin's mosquitocidal effect and in vitro activity against Plasmodium falciparum asexual stages are known. Its in vivo blood-schizonticidal efficacy is unknown. Ivermectin's tolerability and efficacy against P. falciparum infections in Gabonese adults were assess...

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Bibliographic Details
Main Authors: Dorothea Ekoka Mbassi, Ghyslain Mombo-Ngoma, Jana Held, Dearie Glory Okwu, Wilfrid Ndzebe-Ndoumba, Laura Charlotte Kalkman, Franck Aurelien Ekoka Mbassi, Lais Pessanha de Carvalho, Juliana Inoue, Malik Azeez Akinosho, Lia Betty Dimessa Mbadinga, Emmanuel Koffi Yovo, Benjamin Mordmüller, Peter Gottfried Kremsner, Ayôla Akim Adegnika, Michael Ramharter, Rella Zoleko-Manego
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:EBioMedicine
Subjects:
Ivermectin
Plasmodium falciparum
Gabonese adults
Clinical trial
Parasite reduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003808

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http://www.sciencedirect.com/science/article/pii/S2352396423003808

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