Unexpected consequences: exon skipping caused by CRISPR-generated mutations
Abstract A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant allele...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-06-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-017-1240-0 |