Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial
Current efforts to prevent dyslipidemia are focused on the development of functional products as an alternative for hypertriglyceridemia management. This study assessed the metabolic effect of the daily consumption of a bean and oats snack bar (BOSB) on hypertriglyceridemia biomarkers among Mexican...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.890136/full |
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| author | Aurea K. Ramírez-Jiménez Ivan Luzardo-Ocampo Ivan Luzardo-Ocampo M. Liceth Cuellar-Nuñez Miriam Aracely Anaya-Loyola Ma. Fabiola León-Galván Ma. Fabiola León-Galván Guadalupe Loarca-Piña |
| author_facet | Aurea K. Ramírez-Jiménez Ivan Luzardo-Ocampo Ivan Luzardo-Ocampo M. Liceth Cuellar-Nuñez Miriam Aracely Anaya-Loyola Ma. Fabiola León-Galván Ma. Fabiola León-Galván Guadalupe Loarca-Piña |
| author_sort | Aurea K. Ramírez-Jiménez |
| collection | DOAJ |
| description | Current efforts to prevent dyslipidemia are focused on the development of functional products as an alternative for hypertriglyceridemia management. This study assessed the metabolic effect of the daily consumption of a bean and oats snack bar (BOSB) on hypertriglyceridemia biomarkers among Mexican women. An 8-weeks randomized parallel clinical trial (ID: NCT0496694, https://clinicaltrials.gov/ct2/show/NCT04966494) was conducted with 26 hypertriglyceridemic women allocated to BOSB group (TG = 208.18 ± 56.97 mg/dL) and control group (TG = 182.28 ± 51.39 mg/dL). Only the BOSB group consumed 50 g of the product per day. Fasting blood samples were taken from women with an adherence ≥ 90%. A targeted proteomic analysis with plasma samples of control and BOSB groups were conducted using a human obesity antibody array kit and bioinformatic tools provided by the Ingenuity Pathways Analysis (IPA) software. Serum TG levels in the BOSB group decreased by 37.80% (132.04 ± 27.83 mg/dL) compared with the control group (178.87 ± 32.01 mg/dL); glucose levels decreased by 5.69% in the BOSB group (87.55 ± 3.36 mg/dL). A modest body weight (5%) reduction was also found. Forty proteins were differentially modulated by the BOSB consumption (fold change > 1.2). The proteomic analysis revealed the involvement of BOSB bioactives in prevention of monocytes recruitment and localized inflammatory response, inhibition of pre-adipocyte maturation and adipogenesis, inhibition of hepatic b-oxidation, and potential satiety regulation. These results are promising since the mere intervention with the BOSB reduced serum TG without diet restriction, giving insights for further research in prevention of hypertriglyceridemia. |
| first_indexed | 2024-12-12T08:34:09Z |
| format | Article |
| id | doaj.art-8ce390e1d9434b34ab7d381acb4f5479 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T08:34:09Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-8ce390e1d9434b34ab7d381acb4f54792022-12-22T00:30:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-06-01910.3389/fnut.2022.890136890136Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical TrialAurea K. Ramírez-Jiménez0Ivan Luzardo-Ocampo1Ivan Luzardo-Ocampo2M. Liceth Cuellar-Nuñez3Miriam Aracely Anaya-Loyola4Ma. Fabiola León-Galván5Ma. Fabiola León-Galván6Guadalupe Loarca-Piña7Tecnologico de Monterrey, School of Engineering and Science, Monterrey, MexicoResearch and Graduate Program in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Queretaro, MexicoInstituto de Neurobiología, Universidad Nacional Autónoma de México, Queretaro, MexicoFacultad de Medicina, Universidad Autónoma de Querétaro, Querétaro, MexicoFacultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, MexicoLife Science Division, Graduate Program in Biosciences, University of Guanajuato Campus Irapuato-Salamanca, Irapuato, MexicoLife Science Division, Food Department, University of Guanajuato Campus Irapuato-Salamanca, Irapuato, MexicoResearch and Graduate Program in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, Queretaro, MexicoCurrent efforts to prevent dyslipidemia are focused on the development of functional products as an alternative for hypertriglyceridemia management. This study assessed the metabolic effect of the daily consumption of a bean and oats snack bar (BOSB) on hypertriglyceridemia biomarkers among Mexican women. An 8-weeks randomized parallel clinical trial (ID: NCT0496694, https://clinicaltrials.gov/ct2/show/NCT04966494) was conducted with 26 hypertriglyceridemic women allocated to BOSB group (TG = 208.18 ± 56.97 mg/dL) and control group (TG = 182.28 ± 51.39 mg/dL). Only the BOSB group consumed 50 g of the product per day. Fasting blood samples were taken from women with an adherence ≥ 90%. A targeted proteomic analysis with plasma samples of control and BOSB groups were conducted using a human obesity antibody array kit and bioinformatic tools provided by the Ingenuity Pathways Analysis (IPA) software. Serum TG levels in the BOSB group decreased by 37.80% (132.04 ± 27.83 mg/dL) compared with the control group (178.87 ± 32.01 mg/dL); glucose levels decreased by 5.69% in the BOSB group (87.55 ± 3.36 mg/dL). A modest body weight (5%) reduction was also found. Forty proteins were differentially modulated by the BOSB consumption (fold change > 1.2). The proteomic analysis revealed the involvement of BOSB bioactives in prevention of monocytes recruitment and localized inflammatory response, inhibition of pre-adipocyte maturation and adipogenesis, inhibition of hepatic b-oxidation, and potential satiety regulation. These results are promising since the mere intervention with the BOSB reduced serum TG without diet restriction, giving insights for further research in prevention of hypertriglyceridemia.https://www.frontiersin.org/articles/10.3389/fnut.2022.890136/fulloat (Avena sativa)dyslipidemiacommon bean (Phaseolus vulgaris L.)triglyceridestargeted plasma proteomicsmicroarrays |
| spellingShingle | Aurea K. Ramírez-Jiménez Ivan Luzardo-Ocampo Ivan Luzardo-Ocampo M. Liceth Cuellar-Nuñez Miriam Aracely Anaya-Loyola Ma. Fabiola León-Galván Ma. Fabiola León-Galván Guadalupe Loarca-Piña Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial Frontiers in Nutrition oat (Avena sativa) dyslipidemia common bean (Phaseolus vulgaris L.) triglycerides targeted plasma proteomics microarrays |
| title | Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial |
| title_full | Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial |
| title_fullStr | Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial |
| title_full_unstemmed | Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial |
| title_short | Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial |
| title_sort | daily intake of a phaseolus vulgaris l snack bar attenuates hypertriglyceridemia and improves lipid metabolism associated plasma proteins in mexican women a randomized clinical trial |
| topic | oat (Avena sativa) dyslipidemia common bean (Phaseolus vulgaris L.) triglycerides targeted plasma proteomics microarrays |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.890136/full |
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