Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

Abstract Background N6-methyladenosine (m6A) is a dynamic and reversible internal RNA structure of eukaryotic mRNA. YTH domain family 2 (YTHDF2), an m6A-specific reader YTH domain family, plays fundamental roles in several types of cancer. However, the function of YTHDF2 in lung squamous cell carcin...

Full description

Bibliographic Details
Main Authors: Peng Xu, Kang Hu, Ping Zhang, Zhi-Gang Sun, Nan Zhang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cancer Cell International
Subjects:
YTHDF2
Hypoxia
mTOR/AKT
EMT
METTL14
LUSC
Online Access:https://doi.org/10.1186/s12935-021-02368-y

Internet

https://doi.org/10.1186/s12935-021-02368-y

Similar Items