Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice
Abstract We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice. To assess NIHL, 8 week-old mice with and without PQQ administration were exposed to noise for 4 h. PQQ was orally administered for...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19842-w |
| _version_ | 1798001413511446528 |
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| author | Ying Gao Teru Kamogashira Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba |
| author_facet | Ying Gao Teru Kamogashira Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba |
| author_sort | Ying Gao |
| collection | DOAJ |
| description | Abstract We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice. To assess NIHL, 8 week-old mice with and without PQQ administration were exposed to noise for 4 h. PQQ was orally administered for one week before and after noise exposure and subcutaneously once before noise exposure. For ARHL evaluation, mice were given drinking water with or without PQQ starting at 2 months of age. In the NIHL model, PQQ-treated mice had auditory brainstem response (ABR) thresholds of significantly reduced elevation at 8 kHz, a significantly increased number of hair cells at the basal turn, and significantly better maintained synapses beneath the inner hair cells compared to controls. In the ARHL model, PQQ significantly attenuated the age-related increase in ABR thresholds at 8 and 32 kHz at 10 months of age compared to controls. In addition, the hair cells, spiral ganglion cells, ribbon synapses, stria vascularis and nerve fibers were all significantly better maintained in PQQ-treated animals compared to controls at 10 months of age. These physiological and histological results demonstrate that PQQ protects the auditory system from NIHL and ARHL in mice. |
| first_indexed | 2024-04-11T11:35:54Z |
| format | Article |
| id | doaj.art-8ce674ef2d114e2ea5e3e3b52a374a9b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T11:35:54Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8ce674ef2d114e2ea5e3e3b52a374a9b2022-12-22T04:25:58ZengNature PortfolioScientific Reports2045-23222022-09-0112111510.1038/s41598-022-19842-wEffects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in miceYing Gao0Teru Kamogashira1Chisato Fujimoto2Shinichi Iwasaki3Tatsuya Yamasoba4Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of TokyoDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of TokyoDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of TokyoDepartment of Otolaryngology and Head and Neck Surgery, Nagoya City University Graduate School of MedicineDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of TokyoAbstract We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice. To assess NIHL, 8 week-old mice with and without PQQ administration were exposed to noise for 4 h. PQQ was orally administered for one week before and after noise exposure and subcutaneously once before noise exposure. For ARHL evaluation, mice were given drinking water with or without PQQ starting at 2 months of age. In the NIHL model, PQQ-treated mice had auditory brainstem response (ABR) thresholds of significantly reduced elevation at 8 kHz, a significantly increased number of hair cells at the basal turn, and significantly better maintained synapses beneath the inner hair cells compared to controls. In the ARHL model, PQQ significantly attenuated the age-related increase in ABR thresholds at 8 and 32 kHz at 10 months of age compared to controls. In addition, the hair cells, spiral ganglion cells, ribbon synapses, stria vascularis and nerve fibers were all significantly better maintained in PQQ-treated animals compared to controls at 10 months of age. These physiological and histological results demonstrate that PQQ protects the auditory system from NIHL and ARHL in mice.https://doi.org/10.1038/s41598-022-19842-w |
| spellingShingle | Ying Gao Teru Kamogashira Chisato Fujimoto Shinichi Iwasaki Tatsuya Yamasoba Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice Scientific Reports |
| title | Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice |
| title_full | Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice |
| title_fullStr | Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice |
| title_full_unstemmed | Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice |
| title_short | Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice |
| title_sort | effects of pyrroloquinoline quinone on noise induced and age related hearing loss in mice |
| url | https://doi.org/10.1038/s41598-022-19842-w |
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