Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon acti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18261-7 |
| _version_ | 1818344727353753600 |
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| author | Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu |
| author_facet | Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu |
| author_sort | Song Liu |
| collection | DOAJ |
| description | Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability. |
| first_indexed | 2024-12-13T16:51:04Z |
| format | Article |
| id | doaj.art-8cf8cad9388848f799e5b8818620cbce |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:51:04Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8cf8cad9388848f799e5b8818620cbce2022-12-21T23:38:03ZengNature PortfolioNature Communications2041-17232020-09-0111111510.1038/s41467-020-18261-7Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lanceletSong Liu0Shaochun Yuan1Xiaoman Gao2Xin Tao3Wenjuan Yu4Xu Li5Shangwu Chen6Anlong Xu7State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityState Key Laboratory of Biocontrol, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen UniversityLancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability.https://doi.org/10.1038/s41467-020-18261-7 |
| spellingShingle | Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet Nature Communications |
| title | Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| title_full | Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| title_fullStr | Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| title_full_unstemmed | Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| title_short | Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet |
| title_sort | functional regulation of an ancestral rag transposon protorag by a trans acting factor yy1 in lancelet |
| url | https://doi.org/10.1038/s41467-020-18261-7 |
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