Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes

Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes

Abstract Background Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infections (NSTIs). Tissue passage of GAS often results in mutations wit...

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Bibliographic Details
Main Authors: Lea A. Tölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers, Nikolai Siemens
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Biomedical Science
Subjects:
Streptococcus pyogenes
Dendritic cells
Interleukin-18
CovR/S
Necrotizing soft tissue infection
Online Access:https://doi.org/10.1186/s12929-024-01014-9

Internet

https://doi.org/10.1186/s12929-024-01014-9

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