GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

Abstract Background Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dysfunctional cell states fou...

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Bibliographic Details
Main Authors: Anuja Sathe, Carlos Ayala, Xiangqi Bai, Susan M. Grimes, Byrne Lee, Cindy Kin, Andrew Shelton, George Poultsides, Hanlee P. Ji
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Medicine
Subjects:
GITR
TIGIT
Tumor microenvironment
scRNA-seq
Gastric cancer
Colon cancer
Online Access:https://doi.org/10.1186/s13073-023-01259-3

Internet

https://doi.org/10.1186/s13073-023-01259-3

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