CDK4/6 inhibition in cancer: the cell cycle splicing connection

Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma. While investigating the mechanisms of CDK4/6 inhibitor resistance in melanoma, we uncovered a mechanism of action of these inhibitors in regulat...

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Bibliographic Details
Main Authors: Karen E. Sheppard, Shatha AbuHammad
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2019.1673643