Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron–Carbohydrate Nanoparticles from Serum

Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron–Carbohydrate Nanoparticles from Serum

Intravenous (IV) iron nanoparticle preparations are widely used to treat iron deficiency. The mechanism of mononuclear phagocyte system-mediated clearance of IV iron nanoparticles is unknown. The early uptake and homeostasis of iron after injection of ferric carboxymaltose (FCM) in mice was studied....

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Bibliographic Details
Main Authors: Tasneem Arsiwala, Anne-Cathrine S. Vogt, Amy E. Barton, Vania Manolova, Felix Funk, Beat Flühmann, Martin F. Bachmann
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
iron nanomedine
ferric carboxymaltose
monocytes
Kupffer cells
biodisposition
Online Access:https://www.mdpi.com/1422-0067/23/5/2666

Internet

https://www.mdpi.com/1422-0067/23/5/2666

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