Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Abstract Retinoblastoma is the most common intraocular malignancy in children. We previously found that the ACVR1C/SMAD2 pathway is significantly upregulated in invasive retinoblastoma samples from patients. Here we studied the role of an ACVR1C ligand, Nodal, in regulating growth and metastatic dis...

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Bibliographic Details
Main Authors: Laura Asnaghi, David T. White, Lynn Yoon, Antoinette Price, Grace Y. Lee, Arpan Sahoo, Jeff S. Mumm, Charles G. Eberhart
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Neuropathologica Communications
Subjects:
Nodal
Invasion
Proliferation
Retinoblastoma
Online Access:http://link.springer.com/article/10.1186/s40478-019-0785-4

Internet

http://link.springer.com/article/10.1186/s40478-019-0785-4

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