Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.

Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.

The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors counteract by employing tactics to disable lymphocyte NKG2D. This negative dynamic is escalated as some human cancer cells co-opt expression o...

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Bibliographic Details
Main Authors: Xin Cai, Zhenpeng Dai, Rebecca S Reeves, Andrea Caballero-Benitez, Kate L Duran, Jeffrey J Delrow, Peggy L Porter, Thomas Spies, Veronika Groh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4188595?pdf=render

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http://europepmc.org/articles/PMC4188595?pdf=render

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