Neuronal hyperexcitability and ion channel dysfunction in CDKL5-deficiency patient iPSC-derived cortical organoids

Neuronal hyperexcitability and ion channel dysfunction in CDKL5-deficiency patient iPSC-derived cortical organoids

Early epilepsy is a prominent feature in patients with CDKL5-deficiency disorder (CDD). The underlying mechanism for excessive excitability in CDD is largely unknown. The brain organoid model has been recently developed to resemble many critical features of early human brain development. Here, we us...

Full description

Bibliographic Details
Main Authors: Wei Wu, Hang Yao, Priscilla D. Negraes, Juan Wang, Cleber A. Trujillo, Janaina S. de Souza, Alysson R. Muotri, Gabriel G. Haddad
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Disease
Subjects:
CDD
RTT
AP firing
ion channel
cortical organoid
patch-clamp
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002741

Internet

http://www.sciencedirect.com/science/article/pii/S0969996122002741

Similar Items