TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6

TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6

TRPV4 channels, which respond to mechanical activation by permeating Ca<sup>2+</sup> into the cell, may play a pivotal role in cardiac remodeling during cardiac overload. Our study aimed to investigate TRPV4 involvement in pathological and physiological remodeling through Ca<sup>2+...

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Bibliographic Details
Main Authors: Laia Yáñez-Bisbe, Mar Moya, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Marta Tajes, Montserrat Batlle, Eduard Guasch, Aleksandra Mas-Stachurska, Elisabet Miró, Nuria Rivas, Ignacio Ferreira González, Anna Garcia-Elias, Begoña Benito
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
TRPV4
TRPC6
calcium
mechanotransduction
mechanoreceptors
TRP
Online Access:https://www.mdpi.com/1422-0067/25/3/1541

Internet

https://www.mdpi.com/1422-0067/25/3/1541

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