Peptide Blockers of PD-1-PD-L1 Interaction Reinvigorate PD-1-Suppressed T Cells and Curb Tumor Growth in Mice

Peptide Blockers of PD-1-PD-L1 Interaction Reinvigorate PD-1-Suppressed T Cells and Curb Tumor Growth in Mice

The programmed cell death protein 1 (PD-1) plays a critical role in cancer immune evasion. Blocking the PD-1-PD-L1 interaction by monoclonal antibodies has shown remarkable clinical efficacy in treating certain types of cancer. However, antibodies are costly to produce, and antibody-based therapies...

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Bibliographic Details
Main Authors: Shanshan (Jenny) Zhong, Xiaoling Liu, Tomonori Kaneko, Yan Feng, Owen Hovey, Kyle Yang, Sally Ezra, Soon-Duck Ha, Sung Kim, John K. McCormick, Huadong Liu, Shawn Shun-Cheng Li
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Cells
Subjects:
programmed cell death-1 (PD-1)
PD-1 ligand-1 (PD-L1)
immune checkpoint blockade
PD-1/PD-L1 blocking peptide
peptide-based immunomodulator
Online Access:https://www.mdpi.com/2073-4409/13/14/1193

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https://www.mdpi.com/2073-4409/13/14/1193

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