Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months

IntroductionUnderstanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody responses evolved in mild and asymptomatic COVID-19 in Africa and their interactions with SARS-CoV-2 might inform development of targeted treatments and vaccines.MethodsHere, we used a validated indirect in-house...

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Bibliographic Details
Main Authors: Jennifer Serwanga, Violet Ankunda, Jackson Sembera, Laban Kato, Gerald Kevin Oluka, Claire Baine, Geoffrey Odoch, John Kayiwa, Betty Oliver Auma, Mark Jjuuko, Christopher Nsereko, Matthew Cotten, Nathan Onyachi, Moses Muwanga, Tom Lutalo, Julie Fox, Monica Musenero, Pontiano Kaleebu, The COVID-19 Immunoprofiling Team, Patricia Namubiru, Hermilia Christine Akoli, Susan Mugaba, Amina Nalumansi, Kibengo Freddie, Deus Mwesigwa, Joseph Ssebwana Katende
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152522/full