Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia
Although cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clear that microenvironment-mediated epigenetic alterations play important roles. Aberrant promoter hypermethylation is a prevalent phenomenon in human cancers as well as malignant lymphoma/leuk...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/1/568/ |
| _version_ | 1797721650860392448 |
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| author | Atae Utsunomiya Tadashi Yoshino Hiaki Sato Mamoru Ouchida Takashi Oka |
| author_facet | Atae Utsunomiya Tadashi Yoshino Hiaki Sato Mamoru Ouchida Takashi Oka |
| author_sort | Atae Utsunomiya |
| collection | DOAJ |
| description | Although cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clear that microenvironment-mediated epigenetic alterations play important roles. Aberrant promoter hypermethylation is a prevalent phenomenon in human cancers as well as malignant lymphoma/leukemia. Tumor suppressor genes become frequent targets of aberrant hypermethylation in the course of gene-silencing due to the increased and deregulated DNA methyltransferases (DNMTs). The purpose of this article is to review the current status of knowledge about the contribution of cumulative epigenetic abnormalities of the host genes after microbial and virus infection to the crisis and progression of malignant lymphoma/leukemia. In addition, the relevance of this knowledge to malignant lymphoma/leukemia assessment, prevention and early detection will be discussed. |
| first_indexed | 2024-03-12T09:36:12Z |
| format | Article |
| id | doaj.art-8d103a9dde644076872481470b787ac6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T09:36:12Z |
| publishDate | 2011-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8d103a9dde644076872481470b787ac62023-09-02T13:36:11ZengMDPI AGCancers2072-66942011-02-013156858110.3390/cancers3010568Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/LeukemiaAtae UtsunomiyaTadashi YoshinoHiaki SatoMamoru OuchidaTakashi OkaAlthough cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clear that microenvironment-mediated epigenetic alterations play important roles. Aberrant promoter hypermethylation is a prevalent phenomenon in human cancers as well as malignant lymphoma/leukemia. Tumor suppressor genes become frequent targets of aberrant hypermethylation in the course of gene-silencing due to the increased and deregulated DNA methyltransferases (DNMTs). The purpose of this article is to review the current status of knowledge about the contribution of cumulative epigenetic abnormalities of the host genes after microbial and virus infection to the crisis and progression of malignant lymphoma/leukemia. In addition, the relevance of this knowledge to malignant lymphoma/leukemia assessment, prevention and early detection will be discussed.http://www.mdpi.com/2072-6694/3/1/568/epigeneticsmethylationlymphomaleukemiaprogressionHTLV-IH Pylori |
| spellingShingle | Atae Utsunomiya Tadashi Yoshino Hiaki Sato Mamoru Ouchida Takashi Oka Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia Cancers epigenetics methylation lymphoma leukemia progression HTLV-I H Pylori |
| title | Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia |
| title_full | Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia |
| title_fullStr | Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia |
| title_full_unstemmed | Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia |
| title_short | Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia |
| title_sort | cumulative epigenetic abnormalities in host genes with viral and microbial infection during initiation and progression of malignant lymphoma leukemia |
| topic | epigenetics methylation lymphoma leukemia progression HTLV-I H Pylori |
| url | http://www.mdpi.com/2072-6694/3/1/568/ |
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