Gingko biloba-inspired lactone prevents osteoarthritis by activating the AMPK-SIRT1 signaling pathway

Gingko biloba-inspired lactone prevents osteoarthritis by activating the AMPK-SIRT1 signaling pathway

Abstract Background Uncoupled extracellular matrix (ECM) causes cartilage degeneration and osteoarthritis (OA) by suppressing the synthesis and activating the degradation of ECM components. Gingko biloba is a natural Chinese herb with a variety of biological functions; however, the extent to which i...

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Bibliographic Details
Main Authors: Zhijian Zhao, Yang Liu, Yingjie Lu, Mingzhuang Hou, Xu Shen, Huilin Yang, Qin Shi, Yijian Zhang, Fan He, Xuesong Zhu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Arthritis Research & Therapy
Subjects:
Bilobalide
Osteoarthritis
Extracellular matrix
AMPK
SIRT1
Online Access:https://doi.org/10.1186/s13075-022-02890-y

Internet

https://doi.org/10.1186/s13075-022-02890-y

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