Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening

Abstract Background Rhoptry protein 18 (ROP18) is a key virulence factor of Toxoplasma gondii. The host’s immune responses mediated by immune-related GTPases (IRGs) could be blocked by ROP18’s kinase activity. ROP18 also interacts with various substrates, such as activating transcription factor 6 be...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Kun Yin, Guihua Zhao, Chao Xu, Xiao Qiu, Biwei Wen, Hui Sun, Gongzhen Liu, Ye Liu, Qingsong Zhao, Qingkuan Wei, Bingcheng Huang, Ge Yan, Jianping Cao
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: BMC 2019-03-01
Ráidu:Parasites & Vectors
Fáttát:
Virtual screening
Pharmacophore model
Competitive inhibitors
ROP18
Toxoplasma gondii
Liŋkkat:http://link.springer.com/article/10.1186/s13071-019-3341-y

Interneahtta

http://link.springer.com/article/10.1186/s13071-019-3341-y

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