N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells

N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells

Abstract Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent reaction intermediate that is the target of the camptothecin class of chemotherapeutics. Tdp1 two-step catalysis is centered on the fo...

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Bibliographic Details
Main Authors: Evan J. Brettrager, Selma M. Cuya, Zachary E. Tibbs, Jun Zhang, Charles N. Falany, Stephen G. Aller, Robert C. A. M. van Waardenburg
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28564-6

Internet

https://doi.org/10.1038/s41598-023-28564-6

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