AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization

AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization

While anti-angiogenic therapies for wet age-related macular degeneration (AMD) are effective for many patients, they require multiple injections and are expensive and prone to complications. Gene therapy could be an elegant solution for this problem by providing a long-term source of anti-angiogenic...

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Bibliographic Details
Main Authors: Chris P. Hughes, Neil M.J. O’Flynn, Maureen Gatherer, Michelle E. McClements, Jennifer A. Scott, Robert E. MacLaren, Srinivas Goverdhan, Martin J. Glennie, Andrew J. Lotery
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050118301177

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http://www.sciencedirect.com/science/article/pii/S2329050118301177

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