NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Basal forebrain cholinergic neurons (BFCNs) depend on nerve growth factor (NGF) for their survival/differentiation and innervate cortical and hippocampal regions involved in memory/learning processes. Cholinergic hypofunction and/or degeneration early occurs at prodromal stages of Alzheimer’s diseas...

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Bibliographic Details
Main Authors: Valentina Latina, Silvia Caioli, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
nerve growth factor
cholinergic synapse(s)
ubiquitin-proteasome system
ubiquitin-C-terminal hydrolase 1
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00487/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00487/full

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