Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake
Objectives: This study evaluates the intake, tolerability and effect of aged garlic extract (AGE) on cardiovascular markers (blood pressure, body composition, glycemic and lipid parameters), stool consistency and its relationship with dietary factors. Casuistry and Methods: This is a randomized, dou...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005315 |
| _version_ | 1797356139780767744 |
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| author | Tiago M.S. Vila-Nova Kiriaque B. F. Barbosa Analícia R. S. Freire Dennys E. C. Cintra Danielle G. Silva Tânia M. de Andrade Rodrigues Brenda M. Costa Laryssa. G. S. Aragão |
| author_facet | Tiago M.S. Vila-Nova Kiriaque B. F. Barbosa Analícia R. S. Freire Dennys E. C. Cintra Danielle G. Silva Tânia M. de Andrade Rodrigues Brenda M. Costa Laryssa. G. S. Aragão |
| author_sort | Tiago M.S. Vila-Nova |
| collection | DOAJ |
| description | Objectives: This study evaluates the intake, tolerability and effect of aged garlic extract (AGE) on cardiovascular markers (blood pressure, body composition, glycemic and lipid parameters), stool consistency and its relationship with dietary factors. Casuistry and Methods: This is a randomized, double-blind, placebo-controlled clinical trial that included 19 hypertensive volunteers. Participants were randomly treated daily with 1.2 g of AGE (1.2 mg of s-allylcysteine) or placebo for 12 weeks. Mixed model analysis was used to detect possible pressure, dietary and body changes, which were assessed every 4 weeks. At these times the consistency of the stool was also evaluated using the Bristol scale. The biological markers, collected before and after the experimental period (fasting glucose, glycated hemoglobin, total cholesterol, low density lipoprotein, high density lipoprotein, very low-density lipoprotein, triglycerides, and non-HDL cholesterol) were analyzed using parametric tests. Results: Only the AGE group showed significant reductions in systolic levels at week 4 and 12. This pressure variation was correlated with the average intake of vitamin B12 and B9. An improvement in stool consistency was identified only in the experimental group. Modest reductions in biochemical markers were identified in the AGE group and a significant decrease in glycated hemoglobin occurred in the placebo group. There was no significant difference in dietary and anthropometric variables in the treated groups. Conclusion: The 12-week intervention of 1.2 mg of AGE resulted in a decrease in systolic blood pressure and clinical improvements in stool consistency, glycemic parameters and low-density lipoprotein in hypertensive patients with treated but uncontrolled blood pressure. In addition, we found a correlation between the variation in blood pressure levels and the dietary intake of vitamins B9 and B12 in the group treated with AGE. |
| first_indexed | 2024-03-08T14:22:23Z |
| format | Article |
| id | doaj.art-8d258859d4c64c4b9aadc74bd50bd586 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:23Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8d258859d4c64c4b9aadc74bd50bd5862024-01-14T05:37:13ZengElsevierJournal of Functional Foods1756-46462024-01-01112105931Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intakeTiago M.S. Vila-Nova0Kiriaque B. F. Barbosa1Analícia R. S. Freire2Dennys E. C. Cintra3Danielle G. Silva4Tânia M. de Andrade Rodrigues5Brenda M. Costa6Laryssa. G. S. Aragão7Student at the Graduation Program in Nutrition Science, Federal University of Sergipe, São Cristóvão, SE 49100-00, Brazil; Corresponding author.Graduation Program in Nutrition Sciences, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilDepartment of Nutrition, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilFaculty of Applied Sciences, State University of Campinas, Campinas, SP 13083-970, BrazilGraduation Program in Nutrition Sciences, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilDepartment of Morphology, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilStudent at the Graduation in Department of Nutrition, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilStudent at the Graduation in Department of Nutrition, Federal University of Sergipe, São Cristóvão, SE 49100-00, BrazilObjectives: This study evaluates the intake, tolerability and effect of aged garlic extract (AGE) on cardiovascular markers (blood pressure, body composition, glycemic and lipid parameters), stool consistency and its relationship with dietary factors. Casuistry and Methods: This is a randomized, double-blind, placebo-controlled clinical trial that included 19 hypertensive volunteers. Participants were randomly treated daily with 1.2 g of AGE (1.2 mg of s-allylcysteine) or placebo for 12 weeks. Mixed model analysis was used to detect possible pressure, dietary and body changes, which were assessed every 4 weeks. At these times the consistency of the stool was also evaluated using the Bristol scale. The biological markers, collected before and after the experimental period (fasting glucose, glycated hemoglobin, total cholesterol, low density lipoprotein, high density lipoprotein, very low-density lipoprotein, triglycerides, and non-HDL cholesterol) were analyzed using parametric tests. Results: Only the AGE group showed significant reductions in systolic levels at week 4 and 12. This pressure variation was correlated with the average intake of vitamin B12 and B9. An improvement in stool consistency was identified only in the experimental group. Modest reductions in biochemical markers were identified in the AGE group and a significant decrease in glycated hemoglobin occurred in the placebo group. There was no significant difference in dietary and anthropometric variables in the treated groups. Conclusion: The 12-week intervention of 1.2 mg of AGE resulted in a decrease in systolic blood pressure and clinical improvements in stool consistency, glycemic parameters and low-density lipoprotein in hypertensive patients with treated but uncontrolled blood pressure. In addition, we found a correlation between the variation in blood pressure levels and the dietary intake of vitamins B9 and B12 in the group treated with AGE.http://www.sciencedirect.com/science/article/pii/S1756464623005315Aged garlic extractGarlicHypertensionS-allicysteineB vitamins B |
| spellingShingle | Tiago M.S. Vila-Nova Kiriaque B. F. Barbosa Analícia R. S. Freire Dennys E. C. Cintra Danielle G. Silva Tânia M. de Andrade Rodrigues Brenda M. Costa Laryssa. G. S. Aragão Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake Journal of Functional Foods Aged garlic extract Garlic Hypertension S-allicysteine B vitamins B |
| title | Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| title_full | Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| title_fullStr | Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| title_full_unstemmed | Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| title_short | Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| title_sort | effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake |
| topic | Aged garlic extract Garlic Hypertension S-allicysteine B vitamins B |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005315 |
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