The strength of corticomotoneuronal drive underlies ALS split phenotypes and reflects early upper motor neuron dysfunction

Abstract Background Split phenotypes, (split hand, elbow, leg, and foot), are probably unique to ALS, and are characterized by having a shared peripheral input of both affected and unaffected muscles. This implies an anatomical origin rostral to the spinal cord, primarily within the cerebral cortex....

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Bibliographic Details
Main Authors: Andrew Eisen, Peter Bede
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Brain and Behavior
Subjects:
Online Access:https://doi.org/10.1002/brb3.2403