Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Abstract Background Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-relate...

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Bibliographic Details
Main Authors: Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó, Sevil Korkmaz-Icöz
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Heart transplantation
Ischemia
Reperfusion injury
Cathepsin C
Neutrophil elastase
Online Access:https://doi.org/10.1186/s12967-023-04659-6

Internet

https://doi.org/10.1186/s12967-023-04659-6

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