Depletion of CD4+ CD25+ regulatory T cells promotes CCL21-mediated antitumor immunity.

Depletion of CD4+ CD25+ regulatory T cells promotes CCL21-mediated antitumor immunity.

CCL21 is known to attract dendritic cells (DCs) and T cells that may reverse tumor-mediated immune suppression. The massive infiltration of tumors by regulatory T cells (Tregs) prevents the development of a successful helper immune response. In this study, we investigated whether elimination of CD4(...

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Bibliographic Details
Main Authors: Shuang Zhou, Long Chen, Jie Qin, Rilun Li, Huihong Tao, Zhiwei Zhen, Haixia Chen, Guolin Chen, Yaoqin Yang, Binbin Liu, Zhenjue She, Cuiping Zhong, Chunmin Liang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3759453?pdf=render

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http://europepmc.org/articles/PMC3759453?pdf=render

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