Untangling the Conformational Plasticity of V66M Human proBDNF Polymorphism as a Modifier of Psychiatric Disorder Susceptibility

Untangling the Conformational Plasticity of V66M Human proBDNF Polymorphism as a Modifier of Psychiatric Disorder Susceptibility

The human genetic variant BDNF (V66M) represents the first example of neurotrophin family member that has been linked to psychiatric disorders. In order to elucidate structural differences that account for the effects in cognitive function, this hproBDNF polymorph was expressed, refolded, purified,...

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Bibliographic Details
Main Authors: Sonia Covaceuszach, Leticia Yamila Peche, Petr Valeryevich Konarev, Joze Grdadolnik, Antonino Cattaneo, Doriano Lamba
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
proBDNF
V66M polymorphism
structural characterization
conformational plasticity
neuropsychiatric disorders
Online Access:https://www.mdpi.com/1422-0067/23/12/6596

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https://www.mdpi.com/1422-0067/23/12/6596

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