The changing view of insulin granule mobility: From conveyor belt to signaling hub

The changing view of insulin granule mobility: From conveyor belt to signaling hub

Before the advent of TIRF microscopy the fate of the insulin granule prior to secretion was deduced from biochemical investigations, electron microscopy and electrophysiological measurements. Since Calcium-triggered granule fusion is indisputably necessary to release insulin into the extracellular s...

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Bibliographic Details
Main Authors: Bastian Gaus, Dennis Brüning, Sofie Groß, Michael Müller, Ingo Rustenbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
actin
calcium
insulin granules
insulin secretion
pancreatic islet
TIRF microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.983152/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.983152/full

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