Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea Derivatives as Antiproliferative Agents

Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea Derivatives as Antiproliferative Agents

To discover new antiproliferative agents with high efficacy and selectivity, a new series of 1-aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea derivatives (<b>7a</b>–<b>7t</b>) were designed, synthesized and evaluated for their antiproliferative activity against A549, HCT-116...

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Bibliographic Details
Main Authors: Chuanming Zhang, Xiaoyu Tan, Jian Feng, Ning Ding, Yongpeng Li, Zhe Jin, Qingguo Meng, Xiaoping Liu, Chun Hu
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
antiproliferative agent
urea
synthesis
antiproliferative activity
apoptosis
Online Access:https://www.mdpi.com/1420-3049/24/11/2108

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https://www.mdpi.com/1420-3049/24/11/2108

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