Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region

IgG4s are dynamic molecules that undergo a process called Fab-arm exchange. Disulfide bonds between heavy chains are transiently reduced, resulting in half antibodies that reform intact antibodies with other IgG4 half antibodies. In vivo, therapeutic IgG4s can recombine with endogenous IgG4s, result...

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Bibliographic Details
Main Authors: Michael W. Handlogten, Li Peng, Elizabeth A. Christian, Weichen Xu, Shihua Lin, Raghavan Venkat, William Dall’Acqua, Sanjeev Ahuja
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
antibody reduction
Fab-arm exchange
IgG4
disulfide bond
antibody engineering
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1779974

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2020.1779974

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