Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein

Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein

The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation and/or provoke abnormal activity of key enzyma...

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Bibliographic Details
Main Authors: Alicja Kuźniewska, Marcel Thiel, Daria Kowalska, Anna Felberg-Miętka, Patryk Szynkowski, Stanisław Ołdziej, Emilia Arjona, Ilse Jongerius, Santiago Rodriguez de Córdoba, Marcin Okrój, Aleksandra Urban
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
complement system
convertase
MIDAS
molecular modeling
C3 glomerulopathies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061696/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061696/full

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