Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia

Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of EV biogenesis and its relation to Parkinson’s...

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Bibliographic Details
Main Authors: Valerie Sackmann, Maitrayee Sardar Sinha, Christopher Sackmann, Livia Civitelli, Joakim Bergström, Anna Ansell-Schultz, Martin Hallbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
extracellular vesicles
neutral sphingomyelinase 2
α-syn
hypoxia
cell-to-cell transmission
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00200/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00200/full

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