<i>GLA</i> Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease

<i>GLA</i> Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease

Fabry disease (FD) is an X-linked recessive inheritance lysosomal storage disorder caused by pathogenic mutations in the <i>GLA</i> gene leading to a deficiency of the enzyme alpha-galactosidase A (α-Gal A). Multiple organ systems are implicated in FD, most notably the kidney, heart, and...

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Bibliographic Details
Main Authors: Ping Li, Yuqian Xi, Yanping Zhang, Abdus Samad, Wenli Lan, Ya Wu, Jiayu Zhao, Guangxin Chen, Changxin Wu, Qiuhong Xiong
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
fabry disease
kidney
GLA
autophagy
lysosome
mTOR
Online Access:https://www.mdpi.com/2073-4409/13/5/437

Internet

https://www.mdpi.com/2073-4409/13/5/437

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