A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters

A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters

Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the production of viral glycoproteins. Remodelling the secretory pathway presents an op...

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Bibliographic Details
Main Authors: Emmanuel Margolin, Georgia Schäfer, Joel D. Allen, Sophette Gers, Jeremy Woodward, Andrew D. Sutherland, Melissa Blumenthal, Ann Meyers, Megan L. Shaw, Wolfgang Preiser, Richard Strasser, Max Crispin, Anna-Lise Williamson, Edward P. Rybicki, Ros Chapman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Plant Science
Subjects:
SARS-CoV-2
vaccine
glycoprotein
glycosylation
immunogenicity
challenge
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2023.1146234/full

Internet

https://www.frontiersin.org/articles/10.3389/fpls.2023.1146234/full

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