Design, Synthesis, and Biological Evaluation of (E)-N'-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents

Design, Synthesis, and Biological Evaluation of (E)-N'-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late '50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular d...

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Bibliographic Details
Main Authors: H. A. Arjun, Ramakrishnan Elancheran, N. Manikandan, K. Lakshmithendral, Muthiah Ramanathan, Atanu Bhattacharjee, N. K. Lokanath, Senthamaraikannan Kabilan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Chemistry
Subjects:
androgen receptor
prostate cancer
benzohydrazide
molecular docking
molecular dynamics
ADME
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00474/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00474/full

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