Roles of sphingosine-1-phosphate signaling in cancer

Roles of sphingosine-1-phosphate signaling in cancer

Abstract The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is formed by one of two sphingosine kinases (SphKs), SphK1 and SphK2. These enzymes largely exert their...

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Bibliographic Details
Main Authors: Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu, Xun Qi
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cancer Cell International
Subjects:
Cancer progression
Sphingosine-1-phosphate
Sphingosine 1-phosphate receptors
Therapeutic target
Signaling modulators
Online Access:http://link.springer.com/article/10.1186/s12935-019-1014-8

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http://link.springer.com/article/10.1186/s12935-019-1014-8

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