Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein.

Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein.

OBJECTIVES: Survival Motor Neuron (SMN) protein levels may become key pharmacodynamic (PD) markers in spinal muscular atrophy (SMA) clinical trials. SMN protein in peripheral blood mononuclear cells (PBMCs) can be quantified for trials using an enzyme-linked immunosorbent assay (ELISA). We developed...

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Bibliographic Details
Main Authors: Dione T Kobayashi, Douglas Decker, Phillip Zaworski, Karen Klott, Julie McGonigal, Nabil Ghazal, Laurel Sly, Brett Chung, James Vanderlugt, Karen S Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511312?pdf=render

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http://europepmc.org/articles/PMC3511312?pdf=render

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