4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

Abstract Background Pancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor 2 (Nrf2) in macrophages, itaconate is important in a series of inflamma...

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Bibliographic Details
Main Authors: Sunyue He, Yuchen Zhao, Guoxing Wang, Qiaofang Ke, Nan Wu, Lusi Lu, Jiahua Wu, Shuiya Sun, Weihua Jin, Wenjing Zhang, Jiaqiang Zhou
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Medicine
Subjects:
4-Octyl itaconate
Islet injury
Macrophage activation
Type 1 diabetes
Online Access:https://doi.org/10.1186/s10020-023-00626-5

Internet

https://doi.org/10.1186/s10020-023-00626-5

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