HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART

HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART

People with HIV (PWH) on antiretroviral therapy (ART) experience elevated rates of neurological impairment, despite controlling for demographic factors and comorbidities, suggesting viral or neuroimmune etiologies for these deficits. Here, we apply multimodal and cross-compartmental single-cell anal...

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Bibliographic Details
Main Authors: Shelli F. Farhadian, Ofir Lindenbaum, Jun Zhao, Michael J. Corley, Yunju Im, Hannah Walsh, Alyssa Vecchio, Rolando Garcia-Milian, Jennifer Chiarella, Michelle Chintanaphol, Rachela Calvi, Guilin Wang, Lishomwa C. Ndhlovu, Jennifer Yoon, Diane Trotta, Shuangge Ma, Yuval Kluger, Serena Spudich
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-07-01
Series:JCI Insight
Subjects:
AIDS/HIV
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.160267

Internet

https://doi.org/10.1172/jci.insight.160267

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