Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study

Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study

The most common joint disease in the elderly is knee osteoarthritis (OA). It is distinguished by cartilage degradation, subchondral bone loss, and a decrease in joint space. We studied the effects of carnosine (CA) on knee OA in male Wistar rats. OA is induced by anterior cruciate ligament transecti...

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Bibliographic Details
Main Authors: Prabhakar Busa, Sing-Ong Lee, Niancih Huang, Yaswanth Kuthati, Chih-Shung Wong
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
knee osteoarthritis
carnosine
interleukin-1β
reactive oxygen species
nuclear factor erythroid 2-related factor
heme oxygenase
Online Access:https://www.mdpi.com/2076-3921/11/6/1209

Internet

https://www.mdpi.com/2076-3921/11/6/1209

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