Unlocking Synergistic Hepatoprotection: Dapagliflozin and Silymarin Combination Therapy Modulates Nuclear Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway in Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats

Unlocking Synergistic Hepatoprotection: Dapagliflozin and Silymarin Combination Therapy Modulates Nuclear Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway in Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats

This study was aimed to investigate the hepatoprotective potential of dapagliflozin and silymarin alone and in combination to combat carbon tetrachloride (CCl<sub>4</sub>)-induced hepatotoxicity and the anticipated mechanisms. Thirty female Wistar rats were randomly allocated into five d...

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Bibliographic Details
Main Authors: Shakta Mani Satyam, Laxminarayana Kurady Bairy, Abdul Rehman, Mohamed Attia, Layth Ahmed, Karam Emad, Yusuf Jaafer, Abdelrehman Bahaaeldin
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Biology
Subjects:
sodium–glucose co-transporter-2 inhibitors
hepatotoxicity
liver diseases
non-alcoholic fatty liver disease
oxidative stress
repurposing
Online Access:https://www.mdpi.com/2079-7737/13/7/473

Internet

https://www.mdpi.com/2079-7737/13/7/473

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