Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

BackgroundSomatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides are presented on MHC class II (MHCII) vi...

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Bibliographic Details
Main Authors: Peter Symonds, Ana Marcu, Katherine W. Cook, Rachael L. Metheringham, Lindy G. Durrant, Victoria A. Brentville
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
CD4 T cell
citrulline
cancer immunotherapy
peptide elution
post-translational modification (PTM)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.764462/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.764462/full

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