Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailability

Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailability

Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoa...

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Bibliographic Details
Main Authors: Viviana De Caro, Alessia Ajovalasit, Flavia Maria Sutera, Denise Murgia, Maria Antonietta Sabatino, Clelia Dispenza
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Pharmaceutics
Subjects:
mucoadhesive film
sublingual absorption
amorphous solid dispersion
furosemide bioavailability
transmucosal delivery
Online Access:http://www.mdpi.com/1999-4923/9/3/22

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http://www.mdpi.com/1999-4923/9/3/22

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