Complement C5a Receptor 1 Exacerbates the Pathophysiology of <italic toggle="yes">N. meningitidis</italic> Sepsis and Is a Potential Target for Disease Treatment

Complement C5a Receptor 1 Exacerbates the Pathophysiology of <italic toggle="yes">N. meningitidis</italic> Sepsis and Is a Potential Target for Disease Treatment

ABSTRACT Sepsis caused by Neisseria meningitidis (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e., when the systemic inflammatory response is already unleashed. This in turn limits...

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Bibliographic Details
Main Authors: Johannes B. Herrmann, Marcel Muenstermann, Lea Strobel, Alexandra Schubert-Unkmeir, Trent M. Woodruff, Scott D. Gray-Owen, Andreas Klos, Kay O. Johswich
Format: Article
Language:English
Published: American Society for Microbiology 2018-03-01
Series:mBio
Subjects:
C5aR1
Neisseria meningitidis
anaphylatoxins
complement system
inflammation
invasive disease
Online Access:https://journals.asm.org/doi/10.1128/mBio.01755-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01755-17

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