Ligand effects, solvent cooperation, and large kinetic solvent deuterium isotope effects in gold(I)-catalyzed intramolecular alkene hydroamination

Ligand effects, solvent cooperation, and large kinetic solvent deuterium isotope effects in gold(I)-catalyzed intramolecular alkene hydroamination

Kinetic studies on the intramolecular hydroamination of protected variants of 2,2-diphenylpent-4-en-1-amine were carried out under a variety of conditions with cationic gold catalysts supported by phosphine ligands. The impact of ligand on gold, protecting group on nitrogen, and solvent and additive...

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Bibliographic Details
Main Authors: Ruichen Lan, Brock Yager, Yoonsun Jee, Cynthia S. Day, Amanda C. Jones
Format: Article
Language:English
Published: Beilstein-Institut 2024-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkene hydroamination
general acid catalysis
gold catalysis
isotope effect
phosphine ligand effect
solvent effect
Online Access:https://doi.org/10.3762/bjoc.20.43

Internet

https://doi.org/10.3762/bjoc.20.43

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