A novel population of memory‐activated natural killer cells associated with low parasitaemia in Plasmodium falciparum‐exposed sickle‐cell trait children

Abstract Objectives The sickle‐cell trait phenotype is associated with protection from malaria. Multiple molecular mechanisms have been proposed to explain this protection, but the role of the host immune system has been poorly investigated. We hypothesised that cellular immunity to malaria may deve...

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Bibliographic Details
Main Authors: Claire Loiseau, Ogobara K Doumbo, Boubacar Traore, Jamie L Brady, Carla Proietti, Karina P deSousa, Peter D Crompton, Denise L Doolan
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
Online Access:https://doi.org/10.1002/cti2.1125