Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway

Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway

Cancer associated fibroblasts (CAFs) play crucial roles in cancer development, however, the specific mechanisms of CAFs associated renal cancer progression remain poorly understood. Our study observed enriched CAFs in high degree malignant tumor tissues from renal cancer patients. These CAFs isolate...

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Bibliographic Details
Main Authors: Li-bo Chen, Shun-ping Zhu, Tian-pei Liu, Heng Zhao, Ping-feng Chen, You-jun Duan, Rong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
cancer associated fibroblasts
kynurenine
aromatic hydrocarbon receptor
renal cancer
tryptophan 2
3-dioxygenase (TDO)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.628821/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.628821/full

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